MAximising Therapeutic Utility in Rheumatoid Arthritis  

News and publications


1st STRAP site opens outside of the UK
June 2018
The University Hospital Saint-Luc, Brussels opened STRAP in June 2018, this is the first site to open to recrutiment outside of the UK


Salford Royal NHS Foundation Trust joins the STRAP study
April 2018
On the 6th of April 2018 the STRAP study opened for recruitment at Salford Royal NHS Foundation Trust


Financial support secured to open EU sites
Nov 2017
MATURA funders MRC and ARUK agreed financial support for opening STRAP at sites outside of the UK


STRAP study opens at The Royal Wolverhampton NHS Trust
Dec 2017
Two hospitals at the The Royal Wolverhampton NHS Trust, Cannock Chase and New Cross open the STRAP study


100 patients recruited to STRAP!
July 2017
On the 31st of July 2017 the 100th patient was recruited to the STRAP study. The patient was recruited at Basildon hospital.


Kings College Hospital opens the STRAP study
July 2017
Kings College Hospital opened the STRAP study on the 20th of July 2017, joining the 17 other hospitals recruiting patients across the UK


Royal Free Hospital opens STRAP study
May 2017
On the 4th of May 2017 the Royal Free Hospital opened the STRAP study


STRAP study opens at Cambridge
April 2017
The STRAP study opened for patient recruitment on the 11th of April 2017.


STRAP recruitment is a third of the way there
February 2017
STRAP recruitment hit 71 this month, a third of the target recruitment number of 216.


15th STRAP site opens
February 2017
Guy's Hospital opened to recruitment on the 10th of February 2017


Annual MATURA Scientific Symposium held 27th January 2017
January 2017
The annual MATURA Scientific Symposium was held at QMUL on the 27th January 2017. The Scientific Advisory Board attended the meeting and gave positive feedback on the importance of the consortium and the progress made to date. Members of the patient group (MPAG) attended as did over 70 MATURA researchers, the meeting was awarded 5 CPD points.


Congratulations to Simon Stones, NIHR patient research ambassador of the month
January 2017
Patient Research Ambassadors promote and raise awareness of health research in their regions. In January, Simon Stones was awarded ambassador of the month for his work on RA.
Along with many other activities, Simon is a member of the MATURA patient advisory group, MPAG, and provides valuable input to the work of the consortium.


Pharmatics Limited
November 2016
New Industry Partner Pharmatics Limited approved for machine learning application to data analysis within MATURA.


MATURA Patient Advisory Group (MPAG) secure funding from Arthritis Research UK
November 2016
ARUK awarded MATURA £12,000 to support the activities of the MATURA Patient Advisory Group (MPAG).


STRAP study opens at Basildon
November 2016
The fourteenth STRAP site opened on the 3rd of November 2016 when Basildon hospital joined the team.


Homerton given the greenlight for STRAP
October 2016
Homerton hospital opened the STRAP study on the 26th of October 2016


Southend open for STRAP
September 2016
Southend opened for recruitment to STRAP on the 26th September 2016.


Salisbury joins the STRAP study
August 2016
The green light to start recruitment was given to Salisbury on the 23rd of August 2017


Two STRAP sites open in May
May 2016
Leeds and Manchester opened for recruitment to STRAP on the 23rd and 25th of May respectively taking the total number of sites open in the UK to 10.


Prof. Anne Barton is awarded prestigious NIHR Senior Investigator Award
April 2016
Congratulations to Professor Anne Barton, BRU Theme Lead for Inflammatory Arthritis in Adults, who has been chosen as one of just 34 new NIHR Senior Investigators. Senior Investigators represent NIHR’s leading researchers as well as the country’s most outstanding leaders of clinical and applied health and social care research.


Southampton given the green light for STRAP
April 2016
Southampton opened for recruitment to the STRAP study on the 20th April 2016.


All WS1 partners now open for recruitment to STRAP
March 2016
Birmingham opened for recruitment to the STRAP study on the 30th of March 2016, all seven Work Stream 1 partners are now open.


Oxford University Hospital opens for recruitment to STRAP
February 2016
Oxford University Hospital opened for patient recruitment to the STRAP trial on the 25th February 2016.


STRAP study opens at Newcastle
February 2016
The fifth of the 7 partner sites was 'green lighted' on the 11th of February 2016.


STRAP - Cardiff Site Open
January 2016
Cardiff, the fourth STRAP site, opened 19th January 2016.


Protagen AG joins MATURA consortium
December 2015
To support identification of treatment response predictors in Rheumatoid Arthritis:


STRAP - two additional sites open
November 15
University College London Hospital NHS Trust and NHS Greater Glasgow and Clyde (Glasgow Royal Infirmary) were activated on the 2nd and 3rd of November respectively.


1st Patient Randomised
June 15
The first patient was randomised to the STRAP Clinical Study (Work stream 1) on the 8th of June at the Mile End site, Barts.


BSR Meeting
April 15
Special interest group to be held at the BSR to update on progress in stratified medicine initiatives across the UK


Avacta Life Sciences
April 15
New Industry Partner Avacta Life Sciences approved for serum proteomics research within work stream 2


Pfizer and Roche
March 15
STRAP clinical trial – full sponsorship for provision of drug from Pfizer and Roche achieved.
First site initiation visit completed.


February 15
Janssen confirm funding for data amalgamation and expression profiling for MATURA


Protagen Diagnostics
January 15
New Industry Partner Protagen Diagnostics approved for proteomics research within both work streams for MATURA


MATURA Funding
Funding for MATURA health economics research from Innovate UK (TSB) confirmed

Articles/peer reviewed publications and
Lay Summaries

  • Stratified medicine in rheumatoid arthritis-the MATURA programme. Rheumatology (Oxford) vol. 56, (8) 1247-1250.  Barton A, Pitzalis C(2017). 
    DOI: 10.1093/rheumatology/kew369

The MATURA consortium includes academic groups and industry partners working together to identify and test biomarkers
predictive of response to biological therapy in patients with rheumatoid arthritis
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